流行性出血热早期病人尿液6－酮－PGF_（1α）的检测及临床意义

Detection of 6-Keto-PGF_(1α) in the Patients with Early EHF and Its Clinical Significance

采用放射免疫的方法检测了６０例流行性出血热（ＥＨＦ）病人尿液样本９４份。结果显示早期病人（１～４病日组）尿液６－酮－ＰＧＦ_（１α）开始下降，低于正常人水平（Ｐ＜０．０１），这一改变与病情严重程度高度相平行。结果提示ＥＨＦ早期病人肾内ＰＧＩ_２代谢就存在改变，这种变化可能与ＥＨＦ病情加重有关。

Urinary 6-Keto-PGF1α was measured by radioimmunoassay in 60 patients with epidemic hemorrhagic fever(EHF) and 36 healthy voluteers.The results showed that urinary 6-Keto-PGF1α values of the group of EHF in 1～4 days were lower than that of the control group or the group of EHF in 9～20 days(P<0.01).The alterations were more obvious in the groups of severe and dangerous types than that of mild and moderate types and there were statistical significance(P<0.05).It was also observed that there were pasitive correlation between urinary 6-Keto-PGF1α and creatinine clearence rate(Ccr)and between the urinary excretion of 6-Keto-PGF1αand excretion of urinary sodiun.The results indicated that the intrarenal synthesis of PGI2 is specifically altered in the early EHF.Such biochemical alterations were consistent with the severity of the disease.We concluded the alteration might play an importmant role in the progression of EHF.