膀胱内灌注噻替哌和尿激酶预防膀胱癌术后复发

Intravesecal Instillation of thio-tepa and Urokinase in Prevention of recurrence of Bladder Carcinoma after Resection

膀胱内灌注噻哌和尿激酶预防膀胱癌术后复发是一种有效的方法。噻哌中加用尿激酶可以增加噻哌的抗癌效果。将噻哌的剂量减少到４０ｍｇ可以大大减少其对骨髓的抑制作用。噻哌价格低廉、易得，容易被病人所接受。

Intravical instillation of thio-tepa and urokinase is an effective method for prevention of recurrence of bladder cancer after resection.urokinase increases the penetration of thio-tepa into tumor cells and stimulate the release of lysosomal hydrase.It destroys intracellular structure,and thus increases the anticancer effect.Decreases dose of thio-tepa and may reduce its marrow suppressive effect thio-tepa is prices low and easy to obtion is regarded as the first selected method for prevention of recurrence of bladder cancer after resection.