摘要
采用非放射性标记ＤＮＡ技术，检测宫颈鳞癌、宫颈不典型增生和正常宫颈石蜡包埋组织中ＨＰＶ１６ＤＮＡ，阳性率分别为６３．２％、３５．７％，２０．８％。宫颈癌患者ＨＰＶ１６阳性率高于其它两组（Ｐ＜０．００１），宫颈不典型增生Ⅲ级病变的患者中ＨＰＶ１６ＤＮＡ阳性率高于Ⅰ、Ⅱ级病变。结果提示：ＨＰＶ１６感染与宫颈瘤的发生有相关性。
HPV16 DNA sequence was detected by the non-radioactive labelled DNA technique in paraffin-embedded specimens from cerical squamous cell cancer,cervical dysplasia and normal cervical tissue.The results showed that the positive rates of HPV16 DNA sequence were 63.2%,35.7% and 20.8% respectively.The positive rates of HPV16 in cervical cancer was higher than those in cervical dysplasia and normal cervical tissue(P<0.001).However,the positive rate of(HPV16 DNA sequence in cervical dysplasia class Ⅲ lession was higher than that in lessions of class Ⅰ and Ⅱ. The results indicate that infection of HPV16 may be related to the occurrence of cervical cancer.
基金
湖北省教委资助
关键词
子宫肿瘤
鳞状细胞癌
乳头状瘤病毒
cervical neoplasms/ET
carcinoma,squamous cell
infection
papillomaviruses
