冠心病和恶性实体瘤患者血浆脂蛋白a及其它脂类的变化

The Level of Plasma Lipoprotein A and Other Lipids in Patients with Coronary Heart Disease and Malignant Parenchymatous Tumor

观察了冠心病（ＣＨＤ）、恶性实体瘤（ＭＰＴ）病人和正常对照（ＮＣ）者血浆脂蛋白（ａ）（Ｌｐ（ａ））、甘油三酯（ＴＧ）、总胆固醇（ＴＣ）、载脂蛋白Ａ－Ｉ（ＡｐｏＡ－Ｉ）和载脂蛋白Ｂ（ＡｐｏＢ）的水平。结果显示，ＣＨＤ组（１９例）Ｌｐ（ａ）水平（ｍｇ／ｄｌ）为２２．０７±１２．６５，ＭＰＴ组（２６例）为２３．２８±１１．８０，两者均显著高于ＮＣ组（４０例）的１６．６５±７．６１（分别为Ｐ＜０．０５，Ｐ＜０．０１）。ＣＨＤ组ＴＧ、ＴＣ和ＡｐｏＢ均高于ＮＣ组者，ＡｐｏＡ－Ｉ则低于ＮＣ组者。ＭＰＴ组ＴＧ、ＴＣ、ＡｐｏＡ－Ｉ和ＡｐｏＢ均低于ＮＣ组者。作者结合文献分析认为，Ｌｐ（ａ）在ＣＨＤ的发生发展以及ＭＰＴ的增殖与转移中发挥一定的作用。

The levels of plasma lipoprotein A(Lp A),triglyceride(TG),total cholesterol(TC),apolipoprotein A-1(ApoA-1) and apolipoprotein B(Apo B) in patients with coronary heart disease(CHD),malignant parenchymatous tumor(MPT) and in normal controls (NC) were observed.The results showed that the Lp A levels in CHD group(22.07±12.65,n=19) and MPT group(23.28±11.80,n=26) were higher than those in NC group(n=40) which were 16.65±7.61(P<0.05, and P<0.01,respectively).The levels of plasma TG,TC,and ApoB in CHD group were all higher than those in NC group,while that of plasma Aop A-1in CHD group lower than those in NC group.The plasma TG,TC,Apo A-1 and Apo B levels in MPT group were all lower than those in NC group.It is considered that the effect of LP A on the fibrinolytic system is the main reason why Lp A accelerates the progress of athersclersis and promotes the proliferation and metastasis of malignant tumor cells.