系统性红斑狼疮患者血清、尿β_2微球蛋白的测定

Beta2 Microglobulin Determination in Serum and Urine of SLE

对２６例系统性红斑狼疮（ＳＬＥ）患者的血清、尿β２微球蛋白（β２－Ｍ）行放射免疫测定，发现ＳＬＥ患者血β２－Ｍ平均值为４．２６±０．４μｇ／ｍｌ，尿β２－Ｍ平均值为１．７９±０．７１μｇ／ｍｌ均明显高于正常值。同时作了血清抗核抗体（ＡＮＡ）及抗双链ＤＮＡ抗体（Ａｎｔｉ－ｄｓＤＮＡ）的测定。结果表明：血、尿β２－Ｍ的升高与ＳＬＥ病情活动、肾损害程度呈高度相关（ｒ＝０．９７），与ＡＮＡ滴度呈中度相关（ｒ＝０．４６），提示血、尿β２－Ｍ的测定可作为判断病情活动、疗效观察及预后的有效指标。

The β2-microglobulin(β2-M) levels in serum and urine were measured by radioimmunoassay in 26 patients with systemic lupus erythematosus(SLE).The average Values of β2-M in serum and urine were 4.26±0.4μg/ml and 1.79±0.71 μg/ml respectively.Compared with the normal value,the serum and urine levels of β2-Min SLE patients were signifcantly elevated.At the same time,the serum antinuclear antibodies and anti-dsDNA also were measured.The results showed that elevation of β2-M in serum dnd urine were highly correlated with disease activity and severity of renal involvement(r=0.97)and medially correlated with titer of ANA(r=0.46).It is suggested that serous and urinary determination of β2-M is a valuable mark for disease activity,therapeutic response and prognosis.