摘要
采用兔百日咳杆菌脑水肿模型，观察６５４－２的保护作用，结果发现：兔大脑皮质中脑水含量增高、谷氨酸含量显著下降；６５４－２明显减少实验性脑水肿动物的脑水含量、降低脑组织中谷氨酸含量的下降幅度。提示６５４－２对百日咳杆菌脑水肿具有保护作用，其保护机制可能与抑制脑内谷氨酸的大量释放有关。
he
purpose of this studyis to observe the effect of 654-2 on brain edema model in-duced by
pertussis bacilli in rabbits. The results showed that 654-2 declined the water con-tent of brain
and increased the glutamate in brain tissue of treatment group compared withgroup without
treatment. It suggested that 654-2 had protective effect on brain edema induced by pertussis
bacilli.The protective effect of 654-2 was related to inhibition of gluta-mate release from brain
tissue.
出处
《湖南医科大学学报》
CSCD
1995年第2期113-115,共3页
Bulletin of Hunan Medical University
基金
卫生部青年基金
关键词
阿托品衍生物类
654-2
百日咳杆菌
脑水肿
bordetella pertussis
drug effects
brain edema
disease
models,ani-mal
glutamates
atropine derivatives
654-2
rabbits
