Cu·Zn－超氧化物歧化酶治疗类风湿关节炎临床研究

A CLINICAL STUDY ON RHEUMATOID ARTHRITIS TREATED BY CU·Zn-SOD

采用双盲安慰剂对照观察了Ｃｕ·Ｚｎ－超氧化物歧化酶对类风湿关节炎的治疗作用（治疗组２９例，安慰剂对照１０例），发现该剂能明显减轻晨僵、关节肿胀及关节疼痛，降低血沉，改善双手平均握力。表明Ｃｕ·Ｚｎ－超氧化物歧化酶治疗类风湿关节炎有效。

he effects of Cu·Zn-SOD on rheumatoid arthritis were observed in a double blind,placebo controlled clinical study.Thirty-nine patients with definite rheumatoid arthritiswere randomly divided into two groups :SOD group(n=29) was injected with Cu·Zn-SOD80000 unit,q.o. d,intramuscularly for four weeks and placebo was used as control (n=10).After treatment the results showed increased grip strength,shortened duration ofmorning stiffness, less tender joints and swollen joints as well as lower erythrocyte sedimen-tation rate. In the Cu·Zn-SOD group the number of swollen joints was less(P<0.05)andthe effective rate was higher significantly(P<0.01)than that in the placebo controlgroup. The result suggested that Cu·Zn-SOD was effective in treating rheumatoid arthritisand the oxygen free radical scavenger effect of Cu·Zn-SOD might be responsible for itsmechanism.