阿魏酸钠对犬心脏停跳复苏后脑缺血再灌注损伤的影响

EFFECTS OF SODIUM FERULATE ON CEREBRAL ISCHEMIA REPERFUSION INJURY FOLLOWING CARDIAC ARREST AND RESUSCITATION IN DOGS

以脑组织ＭＤＡ，ＧＳＨ含量和ＧＳＨ－ｐｘ，ＳＯＤ活性及超微结构变化为依据，探讨中药当归、川芎的主要活性成分阿魏酸钠（ＳＦ）对犬心脏停跳复苏后脑缺血再灌注损伤的影响。结果表明，与常规治疗组比较，ＳＦ治疗组ＭＤＡ含量明显下降，ＧＳＨ含量和ＧＳＨ－ｐｘ，ＳＯＤ活性增高，脑组织超微结构损伤程度明显减轻。提示ＳＦ可减轻犬心脏停跳复苏后脑缺血再灌注损伤。

he contents of MDA and GSH and the activities of GSH-px and SOD together withthe ultrastructural changes in cerebral tissue were analysed to evaluate the protective effectsof sodium ferulate(SF)on cerebral ischemia reperfusion injury following cardiac arrest andresuscitation in dogs.SF group showed:①a significant reduction in MDA and②an increasein GSH,GSH-px,SOD and③a significant mitigation in cerebral ultrastructural injury incomparision with SIC(standard intensive care)groups;It was considered that SF could miti-gate cerebral ischemia reperfusion injury following cardiac arrest and resuscitation in dogs.