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乙型肝炎患者外周血IL-2与其受体的关系

RELATIONSHIP BETWEEN IL- 2 AND ITS RECEPTOR IN PERIPHERAL BLOOD OF PATIENTS WITH VIRAL HEPATITIS B
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摘要 用生物学方法和间接荧光法分别测定了116例乙型肝炎患者外周血IL-2活性和IL-2R表达率。结果表明:急性黄疸型肝炎、慢性活动性肝炎、慢性重症肝炎和亚急性重症肝炎患者外周血IL-2活性和IL-2R表达率均低于正常对照组(P<0.01);慢性活动性肝炎中两指标的下降水平呈正相关(r=0.6223,P<0.01)。提示检测IL-2R表达水平可了解乙肝患者机体免疫状态。 his study detected interleukin- 2(IL- 2)activity and expression of IL- 2receptor(IL- 2R )of peripheral blood mononuclear cells in 116 cases of viral hepatitis B. The result showedthat IL- 2 activity and expression of IL- 2R decreased in acute icteric hepatitis(AIH),chronicactive hepatitis(CAH),chronic severe.hepatitis(CSH)and subacute severe hepatitis(SSH)in comparison with normal controls(P<0.01).Furthermore,IL- 2R decreased corre- spondingly with IL- 2 falling in hepatitis patients,And,these two parameters showed a directproportion relationship in CAH(r= 0.6223 P<0.01). The data indicate that the patientsimmunity state can be well found by testing IL- 2R expression level;This method has the ad- vantages of saving experimental time and chemical reagents,and is convenient to operate and to observe.
出处 《湖南医科大学学报》 CSCD 1995年第6期582-584,共3页 Bulletin of Hunan Medical University
关键词 病毒性肝炎 白细胞介素 受体 hepatitis,viral,human hepatitis B virus interleukin- 2 receptors,interleukin- 2
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