摘要
用生物学方法和间接荧光法分别测定了116例乙型肝炎患者外周血IL-2活性和IL-2R表达率。结果表明:急性黄疸型肝炎、慢性活动性肝炎、慢性重症肝炎和亚急性重症肝炎患者外周血IL-2活性和IL-2R表达率均低于正常对照组(P<0.01);慢性活动性肝炎中两指标的下降水平呈正相关(r=0.6223,P<0.01)。提示检测IL-2R表达水平可了解乙肝患者机体免疫状态。
his study
detected interleukin- 2(IL- 2)activity and expression of IL- 2receptor(IL- 2R )of peripheral blood
mononuclear cells in 116 cases of viral hepatitis B. The result showedthat IL- 2 activity and
expression of IL- 2R decreased in acute icteric hepatitis(AIH),chronicactive
hepatitis(CAH),chronic severe.hepatitis(CSH)and subacute severe hepatitis(SSH)in comparison
with normal controls(P<0.01).Furthermore,IL- 2R decreased corre- spondingly with IL- 2 falling
in hepatitis patients,And,these two parameters showed a directproportion relationship in CAH(r=
0.6223 P<0.01). The data indicate that the patientsimmunity state can be well found by testing
IL- 2R expression level;This method has the ad- vantages of saving experimental time and
chemical reagents,and is convenient to operate and to observe.
出处
《湖南医科大学学报》
CSCD
1995年第6期582-584,共3页
Bulletin of Hunan Medical University
关键词
病毒性肝炎
白细胞介素
受体
hepatitis,viral,human
hepatitis B virus
interleukin- 2
receptors,interleukin- 2