2－溴甲基－3，5，6－三甲基吡嗪的水解反应动力学

Hydrolysis Kinetics of 2-Bromomethyl-3,5,6-Trimethlpyrazine

以ＨＰＬＣ测定了文题化合物（１）在６０℃和离子强度μ０．１５、ｐＨ１～１１的缓冲溶液中水解反应的反应速度，并以数学处理求得其一级和二级反应的速率常数，以及其共轭酸的一级反应速率常数。研究表明，水解反应的可能机理为Ｓ＿Ｎ１和Ｓ＿Ｎ２。

The rates of hydrolysis of 2-bromomethy 1-3,5,6-trimethylpyrazine to corre-sponding hydroxymethyl compound at 60℃ and ionic strength μ=15 over the pH rangefrom l to l l in buffer solutions were determined by means of HPLC. The reactions weretreated following a apparent first-order kinetical equation,the first-order and the second-or-der reaction rate constants for the substrate and the first-order reaction rate constant for thesubstrate conjugated acid were obtained.The mechanisms of the hydrolysis were proposed tobe S_Nl and S_N 2.