［5－（4－甲脒－苄基）－2，4－二氧代－咪唑烷－3－基］－乙酰基－L－天冬氨酰－L－缬氨酸的合成

Synthesis of [5-(4-Formamidino-Benzyl)-2,4-Dioxo-Imidazolidin-3-yl]-Acetyl-L-Aspartyl-L-Valin(9)

根据由精氨酸－甘氨酸－天冬氨酸组成的肽能抑制血小板聚集的机制，设计并合成了［５－（４－甲脒－苄基）－２，４－二氧代－咪唑烷－３－基］－乙酰基－Ｌ－天冬氨酰－Ｌ－缬氨酸（９）。生物试验结果表明：（９）抑制血小板聚集作用最强，其活性以ＩＣ＿（５０）值相比，强于类似物。

According to the mechanism of the inhibiting action of peptlue Arg-Gly-Asp onplatelet aggregation. Peptide(9)was designed and synthesized.Results of biologic tests showedinhibiting action of(9)on platelet aggregation was the most potent.Its activity was strongerthan that of analogues in comparison with that of IC_(50).