摘要
应用骨髓多染红细胞微核试验研究了环氧乙烷(ethyleneoxide,Eto)的遗传毒性作用。本研究通过亚急性及亚慢性二种方法对Eto的毒性进行了检测。通过实验证明Eto在亚急性条件下,染毒组与对照组比较微核率呈现出极显著的差异。在亚慢性实验条件下,染毒组与对照组比较微核率也呈现极显著差异,说明环氧乙烷确是一个有效的诱变剂。
Using the micronucleus testing for polychromatic erythrocytes of bone marrow in mice, the function of genotoxicity of ethylene oxide (Eto) was studied. The genotoxicity of Eto was tested with subacute and subchronic tests. According to these experiments, there was significant difference on the frequency of micronuclues between the experimental and control groups in subacute test. In addition in subchronic test there was significant difference too. The results indicated that Eto was an effective mutagen.
出处
《华东师范大学学报(自然科学版)》
CAS
CSCD
1995年第4期97-100,共4页
Journal of East China Normal University(Natural Science)
关键词
环氧乙烷
骨髓多染红细胞
微核率
遗传毒性
ethylene oxide micronucleus of polychromatic erythrocytes of bone marrow frequency of micronucleus mutagen