摘要
检测了36例临床诊断为颞下颌关节紊乱综合征(TMJDS)各期(功能紊乱期、结构紊乱期、器质性改变期)患者关节滑液中白介素-6(IL-6)的活性。结果表明:IL-6活性与TMJDS病变程度有关,随病情加重,IL-6活性增高。IL-6水平在一定程度上反映了关节内自身免疫反应的强弱。TMJDS患者关节内在在的骨关节病(OA)病变使软骨中的封闭抗原暴露,诱发自身免疫反应并刺激产生了IL-6,升高的IL-6活性反过来通过增强自身免疫反应来加重TMJOA病变,如此形成恶性循环。对IL-6的研究,有助于解决TMJOA病程迁延、久治不愈的问题,从而使临床治疗更为有效。
Abstract Samples of TMJ synovial fluid were obtained from 36 cases of various stages of TMJDS patients, and the levels of IL-6 in the synovial aspirates were determined and the statistical analysis were made. The results showed that the levels of IL-6 varied from stage to stage of the patients with TMJDS, and they appeared to be highly correlated with the severity of the TMJ osteoarthritic lesions and represented the severity of the autoimmunity in the diseased joint to some extent. The tissue damage in TMJ osteoarthritis that exposed the sequestered antigens in cartilage would provide an opportunity for the generation of autoimmune responses and stimulate the production and release of IL-6. The elevated level of IL-6 accelerated the damage of cartilage by enhencing the autoimmune response.
出处
《华西口腔医学杂志》
CSCD
北大核心
1995年第1期58-60,共3页
West China Journal of Stomatology
基金
国家自然科学基金