颞颌关节紊乱综合征各期患者滑液中细胞因子的研究　第2报　IL－6水平及其意义

A Study on Cytokines in Synovial Aspirates of Various-stage TMJDS Patients Section 2 :IL-6 and Its Significance

检测了３６例临床诊断为颞下颌关节紊乱综合征（ＴＭＪＤＳ）各期（功能紊乱期、结构紊乱期、器质性改变期）患者关节滑液中白介素－６（ＩＬ－６）的活性。结果表明：ＩＬ－６活性与ＴＭＪＤＳ病变程度有关，随病情加重，ＩＬ－６活性增高。ＩＬ－６水平在一定程度上反映了关节内自身免疫反应的强弱。ＴＭＪＤＳ患者关节内在在的骨关节病（ＯＡ）病变使软骨中的封闭抗原暴露，诱发自身免疫反应并刺激产生了ＩＬ－６，升高的ＩＬ－６活性反过来通过增强自身免疫反应来加重ＴＭＪＯＡ病变，如此形成恶性循环。对ＩＬ－６的研究，有助于解决ＴＭＪＯＡ病程迁延、久治不愈的问题，从而使临床治疗更为有效。

Abstract Samples of TMJ synovial fluid were obtained from 36 cases of various stages of TMJDS patients, and the levels of IL-6 in the synovial aspirates were determined and the statistical analysis were made. The results showed that the levels of IL-6 varied from stage to stage of the patients with TMJDS, and they appeared to be highly correlated with the severity of the TMJ osteoarthritic lesions and represented the severity of the autoimmunity in the diseased joint to some extent. The tissue damage in TMJ osteoarthritis that exposed the sequestered antigens in cartilage would provide an opportunity for the generation of autoimmune responses and stimulate the production and release of IL-6. The elevated level of IL-6 accelerated the damage of cartilage by enhencing the autoimmune response.