2－芳基丙酸类消炎镇痛药物的研究2dl－萘普生的新合成法

STUDIES ON THE ANTIINFLAMMATORY DRUGS OF 2-ARYLPROPANOIC ACIDS 2.NEW SYNTHETIC METHOD OF dl-NAPROXEN

以２－甲氧基萘为起始原料，经氯代、氯甲基化、氰化、水解制成２－（５－氯－６－甲氧基－２－萘基）乙酸（４），再经固－液相转移催化直接进行α－单甲基化、脱氯即得ｄｌ－萘普生（１），总收率５１．７％。此法原料易得，操作简便，适合工业化生产。

dl-Naproxen was synthesized from 2-methoxynaphthalene via chloronation, chloromethylation, cyanation, hydrolysis, solid-liquid phase-transfer catalytic α-methylation and dechloronation with a total yield of 51.7%. This method has the advantages of simpler work-up, milder reaction condition and it is applicable to large-scale preparation.