腹腔内热低渗化疗对小鼠腹水瘤生长抑制作用的实验研究

The Inhibitory Effect of Intraperitoneal Hyperthermic and Hypotonic Chemotherapy on Ascites Cancer Cells in Mice

选用ＬＡＣＡ小鼠于其腹腔内植入Ｈ＿（２２）瘤细胞（每鼠２×１０￣７个）２４小时后，分别进行单纯热（４３℃）低渗液、等渗液、顺铂及４３℃低渗液顺铂腹腔内灌注治疗，观察其对小鼠腹水瘤生长的抑制作用。结果发现：以上方法均能破坏腹水瘤细胞，抑制腹水产生，延长小鼠存活天数，以热低渗液顺铂腹腔内灌注的方法效果最好，这可能为临床上防治消化道恶性肿瘤产生癌性腹水提供了一种新的治疗方案。

To study the effect of inhibition of in-traperitoneal hyperthermic hypotonic chemotherapy onthe ascites cacer cells,LACA mice were given in-traperitoneal injection of H_(22) cancer cells (2 × 10￣7 tu-mor cell,each mouse).At 24 hours after the cancerinjection. intraperitoneal simple hyperthermic(43℃)hypotonic fluid group(Ⅱ),isotonic fluid group(Ⅲ ),cis-Diamminodichloroplatinum(DDP)group(Ⅳ)andhyperthermic hypotonic fluid perfusion combined withDDP group(Ⅴ)were processed.The results showed that cancer cells in LACA mice peritoneal cavity were seriously damaged,the ascites growing was obviously inhibited,and the survival days of LACA mice were prolonged in all groups;however,the intraperitoneal hyperthermic hypotonic fluid perfusion with DDP group(Ⅴ)presented greater effect cornpared with the other Rroups。This might be a new therapeutic procedure for the prevention and treatment of cancer ascites in the patients with digestive tract malignan-