硫酸链霉素肺靶向明胶微球的研究

Study on the Lung Targeting Gelatin Microspheres of Streptomycin Sulphate

报道以天然可生物降解的明胶为载体材料，蓖麻油为油相，乳化法制备硫酸链霉素肺靶向明胶微球。微球的平均容积径为９．７μｍ，平均包封率为１５．６９％，经３７℃ＲＨ７５％放置３个月，其含量、外观形态与大小基本不变，热解活化能Ｅ＝７５．８６ｋＪ／ｍｏｌ．体外释药符合Ｈｉｇｕｃｈｉ方程的规律，ｔ＿（１／２）＝８．６ｈ，家兔体内分布微球浓集于肺。

This paper is reported the technologyof lung targeting gelatin microspheres of streptomycinsulphate(SMS).The micropheres were prepared withnatural biodegradable gelatin as the load material andcastor oil as the oil phase。The experimental condi-tions were optimized,the meanVolume diameter ob-tained being 9.7μm and the mean rate of encapsulation15.69%,The content,shape and size of the micro-spheres showed no remarkable change after storage at37C RH 75%for 3 months.Activation energy of heatdecomposition E=75.86kJ/mol.In vitro,the SMS re-lease rate was found to accord with Higuchi equationwith t_1/2=8.6h.In vivo(rabbits)the gelatin micro-spheres were proved to be concentrated in the lung。