阿克拉霉素A在聚氰基丙烯酸异丁酯毫微粒上的吸附规律研究

Adsorption of Aclacinomycin A onto Polyisobutylcyanoacrylate Nanoparticles

阿克拉霉素Ａ在聚氰基丙烯酸异丁酯毫徽粒土的吸附在１５分钟内即可达平衡。吸附量受胶体颗粒表面电荷密度、溶液ｐＨ、溶液离子强度及温度等多种因素的影响。较高的胶体＊粒表面电荷密度、较低的溶液ｐＨ、较高的溶液离子强度及较低的温度均有利于吸附量增加。吸附等温线可用Ｆｒｅｕｎｄｌｉｃｈ经验公式描述为Ｙ＝１．０１８８Ｃ￣０．６４９４，（ｒ＝０．９９４５）ｉ也可用Ｌａｎｇｍｕｉｒ吸附等温式表述为Ｃ／Ｙ＝０．７３６３Ｃ＋０．４０２７，（ｒ＝０．９３３１）。吸附机理主要是静电与离子性相互作用。

The mechanism ofadsorption of acla-cinomycin A onto polyisobutylcyanoacrylate nanoparti-cle and the factors effecting the adsorption werestudied,The adsorption process reacked equilibrium in15 minutes.Ther results showed that the surhcecharge densities of the nanoparticles,pH, ionicstrength and temperature effected the adsorption, Ad-sorption isotherms of aclacinomycin A onto poly-isobut yl cyanoacrylate nanoparticles could be de describedwith Freundlich equation Y=1.0188 C￣(0.6494)(r=0.9945)and with Langmuir equation C/Y=0.7363C+0.4027(r=0. 9331)respectively. The main actionsbetween aclaci nomycine A and polyisobutyl-cyanoacrylate nanoparticles were electrostatic and ionic action.