血清可溶性白细胞介素Ⅱ受体检测在环孢素治疗狼疮肾炎中的应用

The Use of Measuring Serum Soluble IL-2 Receptor Levels in Cyclosporine-A Treated Lupus Nephritis

对比观察２１例狼疮肾炎患者用环孢素治疗前后血清可溶性白细胞介素Ⅱ受体（ＳＩＬ－２Ｒ）变化。结果显示：治疗后血清ＳＩＬ－２Ｒ比治疗前明显降低，其程度与２４小时尿蛋白和抗核抗体成正相关，与补体Ｃ３、ＣＨ５０呈负相关。由此提示：血清ＳＩＬ－２Ｒ是观察环孢素治疗狼疮肾炎疗效的一个良好指标。

Twenty-one patients with LupusNephritis(LN ) were treated with cyclosporine-A(CsA)for three months.Serum soluble interleukin-2receptors(SIL-2R)were measured before and aftertreatment and correlated prospectively with serologicfindings of LN activity. The patients had significantlyhigher IL-2R level before treatment (during LN flare)than after treatment (disease remission).Asiqnificantpositive correlation was present between serum SIL-2R and proteinuria,and ANA as well,whereas theSIL-2R levels in LN patients were inversely correlatedwith serum levels of C3 and CH50.These observationssuggest that serum SlL-2R level is an useful marker ofdisease activity in LN and may serve as a helpful ad-junct in the management of this disorder.