原发性干燥综合征的临床及免疫学变化的观察

An Investigation of the Clinical and Immunologic Manifestation in Patients with Primary Sjogren's Syndrome

本文报道１２５例符合国际诊断标准，确诊为原发性干燥综合征（ＰＳＳ）患者的临床及免疫学变化。对全部患者进行了口干燥症及眼干燥症的有关检测各四项，并进行了血液流变学及免疫学改变的检测。结果表明ＰＳＳ好发于４０岁以上的女性患者，临床表现主要有口干、眼干、鼻干、关节疼痛等。诊断依据为口干燥症、干燥性角结膜炎（ＫＣＳ）及血液免疫学异常中具有两项并排除其他结缔组织病者，则ＰＳＳ的诊断确立。本组患者免疫学改变主要有Ｔ淋巴细胞亚群及比值异常，高丙种球蛋白血症、抗ＳＳＡ及抗ＳＳＢ抗体阳性，但因阳性率仅２５．６～４４．８％，故阴性不能排除本病的可能。

In an investigation of 125 cases of.primary Sjogren's Syndrome(PSS) who admitted in WCUMS Hospital is reported.The results showed that the majority of cases(104) were femal and 101 cases were over 40 years of age.The main manifestation are dry eyes(101 cases),dry mouth(85 cases) joint pain(81 cases),hypergamaglobulinemia(65 cases) and abnormal Tcell subsets.It is demonstrated that autoantibodies had beeddetected in serum, espacially anti SSA and anti SSB antibodies are sensitive andspecific markers in the diaguosis of PSS.