格氏试剂交叉偶联反应制备α－三联噻吩

Cross-coupling reaction of Grignard reagent with thiophenyl handes by using nickel phosphine as catalyst and the synthesis of α-tertkienyl

利用镍－膦络合物Ｎｉ（ＰＰｈ３）２Ｃｌ２、Ｎｉ（ＰＢｕ３）２Ｃｌ２、Ｎｉ（ｄＰＰｅ）Ｃｌ２、Ｎｉ（ｄＰＰＰ）Ｃｌ２以及无膦配体的ＮＩＣｌ２作为催化剂，能有效促进格氏试剂与溴代噻吩的交叉偶联反应，方便制取α－三联噻吩。

The use of nickel phosphine complexes Ni(PPh3)2Cl2, Ni(PBu2),Cl2, NiCl2(dppp), NICl2(dppe) andanhydrous NiCl2 (free of ligand) has effectivelypromoted the cross-coupling reaction of Grignardreagent with thiophenyl handes. This reaction can beeasily applied to the synthesis of a-terthienyl.