配体与金属硫蛋白反应动力学和机理研究

Kinetics and Mechanism Studies of Reaction of Metallothionein with Some Ligands

制备了Cd_7Th,Zn_7Th,Pb_7Th,Hg_7Th,Bi_7Th等一系列金属硫蛋白(Thionein简称Th),研究了它们与配体反应的动力学,根据表观假一级反应速率常数,提出了不同配体与金属硫蛋白反应的两种机理,并且讨论了金属硫蛋白被Cd^(2+),Pb^(2+),Hg^(2+)等重金属离子在体内诱导的不同形成行为.

Cd7Th, Zn7Th, Bi7Th, Hg7Th and Pb7Th have been prepared, and the kinetics of reactions of these five MTs with varied ligands were discussed. From the observed pseudo-first order rate constants, two possible mechanism were determined respectively. The reason of induction behaviors of varied heavy metal ions in vivo also was suggested on the basis of above results.