环境镉污染区人群尿N－乙酰－β－D－氨基葡萄糖苷酶的活性变化

Urinary N-acetyl-β-d-glucosaminidase (NAG) Activities of the People Living a Cd-polluted Area

观察了７４名居住在含铜废水灌溉区２５年以上的居民尿中ＮＡＧ活性变化。通过与同期测定的尿镉、血镉和β_（２－）微球蛋白等指标的比较分析发现，长期低剂量镉暴露可引起人群尿ＮＡＧ活性的增加。尿ＮＡＧ活性测定在监测镉对人群的早期毒性危害中是一个较为理想的生物监测指标。

Urinary NAG and β_2-microglobulin, urinary and blood cadmium were determined, the samples were collected from 74 subjects living an environmental Cd-polluted area and 74 people from non-polluted area respectivily. The usefulness of urinary NAG as biological indicator of renal damage caused by cadmium exposure was compared with other indicators measured. The result showed that cadmium exposure can increase the people's urinary NAG activity and the change of urinary NAG activity is a sensitive and useful indicator of renal damage at early stage of cadmium nephrotoxity.