儿茶酚胺对培养的小鼠皮肤导电性和表皮缝隙连接的影响

EHect of Catecholamine on the Conductance and Epidermis Gap Junction in Cultured Mouse Skin

在培养的小鼠皮肤上研究了儿茶酚胺类物质对皮肤导电性和表皮缝隙连接的影响。主要结果为：（１）在适当浓度下，肾上腺素和异丙肾上腺素均可使皮肤导电性增加，而浓度过高时，肾上腺素则使皮肤导电性下降；（２）仅当皮肤与肾上腺素培养一定时间之后，才能显示导电性增加的反应；（３）肾上腺素类物质使皮肤导电性增加的作用需要有谷氨酰胺存在；（４）肾上腺素使皮肤导电性增加的实验条件也能使表皮缝隙连接的面数密度显著增加。

n in vitro study concerning the effect ofcatecholamine on the skin conductance and epidermis gap junctionwas carried out usingcultured mouse skin. The results were as follows.(1)The skin conductance was increased bysuitable concentration of epinephrine and isoproterenol,while decreased by high concentration of epinephrine;(2)Increase in skin conductance appeared only after a period of time of incubation with epinephrine(3)In the effect ofepinephrine on skin coductance increase glutamine was involved;(4)The area density of gap junction in epidermiswas increased by epinephrine in the condition under which the skin conductance was increased.