P6A和RGDS对离体大鼠缺血／再灌注心肌的保护作用

Protective Effects of P6A and RGDS on the Isolated Ischemia-reperfusion Rat Hearts

本工作观察两种新型抗凝剂Ｐ６Ａ和ＲＧＤＳ对缺血／再灌注心肌的保护作用。结果表明：再灌注期给予１０￣（－５）ｍｏｌ／Ｌ的Ｐ６Ａ可显著降低再灌注心律失常的发生率，减轻再灌心肌的脂质过氧化和钙超载；１０￣（－６）ｍｏｌ／Ｌ的ＲＧＤＳ具有相似的作用，但二者对心肌局部血管紧张素Ⅱ的生成无明显影响，提示Ｐ６Ａ和ＲＧＤＳ可能是通过调节心肌细胞内的钙稳态来拮抗钙超载的发生，发挥其心肌保护作用。

he effect of P6A and RGDS on isolated rat hearts during ischemia-reperfusion was investi-gated by using Langendorff’s perfusion model. The results show that theheart perfused withCaptopril(10￣(-6)mol/L),P6A(10￣(-5)mol/L)or RGDS(10￣ (-6)molthe incidence of reperfusing ar-rhythmia decreased and myocardium calcium content and MDA reduced significantly. But perfu-sion with P6A or RGDS could not repress AGT Ⅱsynthesis in local myocardium. The resultssuggested that P6A and RGDS may be participate in regulating the introcellular calcium home-ostasis and protected myocardium from ischemia-reperfusion injury.