糖皮质激素对兔中性粒细胞CD＿（18）表达的影响及其机理探讨

Effects of Glucocorticoid on CD_(18) Expression on Rabbit Polymorphonuclear(PMN ) and Its Mechanism

兔中性粒细胞（ＰＭＮ）表面有ＣＤ＿（１８）的基础表达，地塞米松（ＤＥＸ）可使其表达减少，并具有剂量依赖性；用糖皮质激素受体（ＧＲ）阻断剂ＲＵ３８４８６和ＤＥＸ同时处理ＰＭＮ，随着ＤＥＸ／ＲＵ３８４８６浓度比的下降，ＣＤ＿（１８）表达逐渐增加；单纯用ＲＵ３８４８６处理ＰＭＮ，对ＣＤ＿（１８）的表达无明显作用。本研究结果提示ＤＥＸ通过ＧＲ的介导，抑制了兔ＰＭＮＣＤ＿（１８）的表达。

here is a basic CD_(18) expression on rabbit PMN,which is reduced by dexamethasone(DEX)andis dose dependent.PMN being treated with glucocorticoid receptor(GR) antago-nist RU38486 and DEX simultaneously,CD_(18) expression increases gradually as the result ofreducing of DEX to RU38486 concentration ratio. Treatment with RU38486 has no effect onCD_(18) expression, The results suggest that DEX inhibits CD_(18) expression on rabbit PMN,which is mediated by GR.