rhEDIL－8对大鼠失血性休克血浆6－keto－PGF_（1α）和TXB_2含量的影响

EFFECTS OF INTERLEUKIN-8 ON 6-KETO-PGF_(1α) AND TXB_2 PLASMA CONTENTS IN RATS WITH HEMORRHAGIC SHOCK

应用放射姓免疫分析技术观察ｒｈＥＤＩＬ－８对大鼠晚期失血性休克血浆６－ｋｅｔｏ－ＰＧＦ_（１α）和ＴＸＢ_２含量的影响，并与ＭＡＢＰ的变化作相关性分析。结果发现晚期失血性休克血浆６－ｋｅｔｏ－ＰＧＦ_（１α）含量明显降低（Ｐ＜０．０１），ＴＸＢ_２含量明显升高（Ｐ＜０．０１）；给予ｒｈＥＤＩＬ－８（２５０μｇ／ｋｇ）静脉注射后血浆６～ｋｅｔｏ－ＰＧＦ_（１α）含量明显升高，其血浆水平与ＭＡＢＰ呈明显的正相关性（ｒ＝０．７４６）；ｒｈＥＤＩＬ－８对血浆ＴＸＢ_２含量却无明显影响。研究结果提示：ｒｈＥＤＩＬ－８抗晚期失血性休克作用与其促进血管内皮细胞产生和释放ＰＧＩ_２有关。

The effect of recombinant human edothelial-dirived interleukin-8(rhEDIL-8)on 6-keto-PGF_(1α) and TXB_2 plasma contents in rats with hemorrhagic shock was studied by radioimmunoassay.The results showed that the plasma content of 6-keto-PGF_(1α) was significantly decreased(P<0.01) and the plasma content of TXB_2 was increased obviously(P<0.01) during profound hemorrhagic shock.After reperfusion and administration of rhEDIL-8(250μg/kg),the plasma content of 6-keto-PGF_(1α) was remarkably increased and its levels significantly correlated with that of mean arterial blood pressure(r=0.746).But rhEDIL-8 has not obvious effect on TXB_2 plasma content.The results suggest that rhEDIL-8 enhance vascular endothelium release PGI_2 may be the mechanisma of its antishock effects.