阿司匹林抵抗的研究进展

Researches of aspirin resistance

患者尽管服用阿司匹林,但缺血性血管事件仍时有发生,故认为可能与阿司匹林抵抗(Aspirinresistance,AR)有关。阿司匹林抵抗有临床定义和实验室检测血小板活性定义2种,可分为3种不同类型。AR不仅存在于健康人,也可发生在不同疾病患者中,发病机制有多种可能。不同类型AR患者,可以通过增加阿司匹林剂量或通过使用其他抗血小板制剂获益。

A significantnumber of individuals suffer ischemic vascular events despite taking aspirin. They appear to have “aspirin resistance （AR）”. AR have two definitions, clinical AR, i.e. the inability of aspirin to protect a person from ischemic vascular events, and biochemical AR, i.e., the inability of aspirin to oroduce an anticipated effect on one or more tests of platelet activity. AR can be classified into three different types. Aspirin resistance lies in not only healthy population but also individuals who suffer from variety of illnesses. It has many possible causes. The most efficient strategies for clinicians to treat patients of AR are to increase aspirin dosage or/and use the alternative platelet inhibitors.