摘要
目的探讨抗精神病药所致迟发性运动障碍(TD)患者体内自由基代谢状况与TD的关系。方法测定119例TD(TD组)、46例非TD(非TD组)慢性精神分裂症患者及44名正常人(对照组)血浆超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(Gpx)、过氧化氢酶(CAT)活性及丙二醛(MDA)浓度,并在TD组中选取46例一般状况与非TD组、对照组匹配的患者进行三组间方差分析;生化指标与异常不自主运动量表(AIMS)总分间的相关性采用直线相关分析。结果(1)对照组血浆SOD活性[(98±11)×103U/L]、Gpx活性[(143±31)×103U/L]高于TD患者[44例,SOD(85±15)×103U/L,Gpx(101±29)×103U/L]及非TD组[SOD(93±16)×103U/L,Gpx(117±39)×103U/L];对照组MDA浓度[(2.6±1.5)mmol/L]低于TD患者[44例,(13.5±8.8)mmol/L]及非TD组[(7.3±6.5)mmol/L],差异均有统计学意义(均P<0.05);(2)TD患者(44例)血浆SOD活性、MDA浓度与非TD组间的差异均有统计学意义(均P<0.05);(3)AIMS总分与SOD、MDA均有显著相关(r=-0.225,r=0.225,均P<0.05)。结论TD患者的血浆抗氧化酶、脂质过氧化物异常,自由基代谢障碍可能与TD关系密切。
Objective To investigate the changes of plasma superoxide dismutase (SOD), catalase(CAT) , glutathione peroxidase (Gpx) activities and malondialdehyde (MDA) level in patients with tardive dyskinesia (TD). Methods The plasma activities of SOD, Gpx, CAT and the level of MDA in normal volunteers ( n = 44), schizophrenic patients with TD ( n = 119) and schizophrenic patients without TD ( non-TD, n = 46) were assayed, 46 patients with TD whose age, medication, illness duration matched with non-TD were selected to make comparison. Results ( 1 ) The plasma activities of SOD [ (98 ± 11 )× 10^3 U/L ],Gpx [ ( 143 ± 31 )× 10^3 U/L] in normal controls were significantly higher than that in patients with TD[SOD (85± 15) × 10^3U/L, Gpx (101 ± 29) × 10^3 U/L], and non-TD[SOD (93± 16) ± 10^3 U/L, Gpx(117±39) ×10^3 U/L], (P〈0.05), and the plasma level of MDA [(2.6±1.5) mmol/L] in normal controls were significantly lower than that in patients with TD [ ( 13.5 ± 8. 8 ) mmol/L ], and non-TD [ (7. 3±6.5) mmol/L] ; (2) There was significant difference (P 〈 0. 05) between the TD and non-TD group in the SOD and MDA ; ( 3 ) The correlation coefficients between the activities of SOD, lever of MDA and the AIMS total score in all patients with TD were - 0. 225 and 0. 225 respectively ( P 〈 0.05 ). Conclusion The plasma antioxidants and MDA in the patients with TD were abnormal. Oxidative damages may be involved in the development of TD.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2005年第3期142-145,共4页
Chinese Journal of Psychiatry
基金
首都医学发展科研基金资助项目(20023095)
北京大学211工程循证医学科学群资助项目(95000246156082)