抗精神病药所致迟发性运动障碍患者血浆超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化酶活性及丙二醛浓度的改变

The changes of plasma superoxide dismutase,catalase,glutathione peroxidase,maleic dialdehyde in patients with antipsychotics-induced tardive dyskinesia

目的探讨抗精神病药所致迟发性运动障碍(TD)患者体内自由基代谢状况与TD的关系。方法测定119例TD(TD组)、46例非TD(非TD组)慢性精神分裂症患者及44名正常人(对照组)血浆超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(Gpx)、过氧化氢酶(CAT)活性及丙二醛(MDA)浓度,并在TD组中选取46例一般状况与非TD组、对照组匹配的患者进行三组间方差分析;生化指标与异常不自主运动量表(AIMS)总分间的相关性采用直线相关分析。结果(1)对照组血浆SOD活性[(98±11)×103U/L]、Gpx活性[(143±31)×103U/L]高于TD患者[44例,SOD(85±15)×103U/L,Gpx(101±29)×103U/L]及非TD组[SOD(93±16)×103U/L,Gpx(117±39)×103U/L];对照组MDA浓度[(2.6±1.5)mmol/L]低于TD患者[44例,(13.5±8.8)mmol/L]及非TD组[(7.3±6.5)mmol/L],差异均有统计学意义(均P<0.05);(2)TD患者(44例)血浆SOD活性、MDA浓度与非TD组间的差异均有统计学意义(均P<0.05);(3)AIMS总分与SOD、MDA均有显著相关(r=-0.225,r=0.225,均P<0.05)。结论TD患者的血浆抗氧化酶、脂质过氧化物异常,自由基代谢障碍可能与TD关系密切。

Objective To investigate the changes of plasma superoxide dismutase （SOD）, catalase（CAT） , glutathione peroxidase （Gpx） activities and malondialdehyde （MDA） level in patients with tardive dyskinesia （TD）. Methods The plasma activities of SOD, Gpx, CAT and the level of MDA in normal volunteers （ n = 44）, schizophrenic patients with TD （ n = 119） and schizophrenic patients without TD （ non-TD, n = 46） were assayed, 46 patients with TD whose age, medication, illness duration matched with non-TD were selected to make comparison. Results （ 1 ） The plasma activities of SOD [ （98 ± 11 ）× 10^3 U/L ],Gpx [ （ 143 ± 31 ）× 10^3 U/L] in normal controls were significantly higher than that in patients with TD[SOD （85± 15） × 10^3U/L, Gpx （101 ± 29） × 10^3 U/L], and non-TD[SOD （93± 16） ± 10^3 U/L, Gpx（117±39） ×10^3 U/L], （P〈0.05）, and the plasma level of MDA [（2.6±1.5） mmol/L] in normal controls were significantly lower than that in patients with TD [ （ 13.5 ± 8. 8 ） mmol/L ], and non-TD [ （7. 3±6.5） mmol/L] ; （2） There was significant difference （P 〈 0. 05） between the TD and non-TD group in the SOD and MDA ; （ 3 ） The correlation coefficients between the activities of SOD, lever of MDA and the AIMS total score in all patients with TD were - 0. 225 and 0. 225 respectively （ P 〈 0.05 ）. Conclusion The plasma antioxidants and MDA in the patients with TD were abnormal. Oxidative damages may be involved in the development of TD.