丙二酰二醛修饰的低密度脂蛋白与冠心病的相关性研究

The relationship between malondialdehyde-modified low-density lipoprotein and coronary heart disease

目的探讨丙二酰二醛修饰的低密度脂蛋白(MDALDL)与冠心病及其他血脂之间的关系。方法选择冠心病患者组68例,正常对照组74名。采用酶联免疫吸附分析(ELISA)的方法检测人血清中MDALDL,同时对受检者的血脂水平进行检测,结果进行统计学分析。结果冠心病患者血清氧化低密度脂蛋白(oxLDL)水平为(115.62±53.4)U/L,明显高于正常对照组(86.7±27.6)U/L(P<0.05);MDALDL与低密度脂蛋白胆固醇(LDLC)水平的比值在冠心病患者组为(43.25±2.64)mmol/U,明显高于正常对照组(33.74±1.58)mmol/U(P<0.01)。血清总胆固醇(TG)、LDLC与MDALDL水平呈显著正相关,相关系数r=0.486,而高密度脂蛋白胆固醇(HDLC)与MDALDL水平呈负相关,相关系数r=0.402。结论MDALDL与冠心病有着非常密切的关系,参与冠心病的发生发展过程。

Objective To investigate the correlation between blood lipids like malondialdehydemodified low-density lipoprotein （MDA-LDL） and coronary heart disease. Methods 68 coronary heart disease patients plus 74 healthy controls were randomly chosen, and ELISA was used to determine serum MDA-LDL levels. Blood lipid levels were also determined. All results were subjected to statistical analysis. Resets Ox-LDL were significantly higher in coronary heart disease group（ 115.62 ± 53.4） U/L than in healthy controls （ 86.7 ± 27.6 ） U/L （ P 〈 0.05 ） ; the ratio of MDA-LDL to LDL-C were also significantly higher in coronary heart disease group （43.25 ±2. 64 ） mmol/U than in healthy controls （33.74 ± 1.58） mmol/U, （ P 〈 0. 01 ）. TG, LDL-C and MDA-LDL were positively correlated, related coeffcient r=0.486, while HDL-C and MDA-LDL were inversely correlated, related coefficient r = 0. 402.Conclusion MDA-LDL were correlated with coronary heart disease, and may take part in the pathogenesis of coronary heart disease.