老年2型糖尿病血栓调节蛋白检测的临床意义

Thrombomodulin in the elderly with type 2 diabetes

目的研究老年2型糖尿病患者慢性血管并发症的形成与血栓调节蛋白(TM)的关系。方法采用双抗体夹心酶联免疫吸附法检测128例老年2型糖尿病患者和40例正常对照者血栓调节蛋白(TM)水平。结果糖尿病组血浆TM水平显著高于正常对照组,差异有显著性(P<0.05);胃血管病变组(A组)的血浆TM显著高于无血管病变组(B组),差异有显著性(P<0.05)。结论TM水平反映了血管内皮细胞受损伤程度,血浆TM水平仅在糖尿病出现并发症时升高,因而认为TM可作为判断糖尿病患者出现血管并发症的指标。

Objective To study the relationship between thromobomodulin （TM）and chronic vascular complication in the elderly with type 2 diabetes. Methods The plasma level of TM was measured by ELISA in 128 elderly patients with type 2 diabetes and 40 normal controls, Results The plasma level of TM in elderly patients with type 2 diabetes was significantly higher than that in normal controls （ P 〈 0.05 ）. The plasma level of TM in group of elderly patients with type 2 diabetes with vascular complications was significantly higher than that in those without vascular complications （ P 〈0. 05 ）. Conclusions The plasma level of TM reflects the damage degree of the vascular endothelial cell. Thrombomodulin can be used as an indicator for vascular complications occurring in diabetes.