骨髓活检与涂片同步观察对诊断多发性骨髓瘤的探讨

Synchronism Observation on Both Marrow Biopsy and Marrow Smear in Multiple Myeloma

目的探讨骨髓活检和骨髓涂片同步观察在多发性骨髓瘤(MM)诊断临床意义。方法对24例MM患者,采用骨髓抽吸活检双标本一步法取材,同时观察其骨髓涂片和活检塑料包埋切片。结果骨髓造血组织增生度在2+以上者,切片为91.67%,而涂片为58.33%,3+以上切片占41.67%,涂片16.67%,两者差异存在显著性意义(P<0.05)。骨髓涂片和切片相结合有助于MM的诊断和分型。结论诊断多发性骨髓瘤的同步观察比常规涂片形态学观察的检出率明显增高。

Objective To study the diagnostic value of synchronism observation on bone marrow biopsy and bone marrow smear in multiple myeloma （MM）. Methods The marrow samples of 24 patients with multiple myeloma were detected by bone marrow biopsy and bone marrow smear. Those sections and smears were observed. Results When the proliferating degree of the marrow was 2 ＋, the positive ratio of hyperplasia in marrow section was 91.67% and the positive ratio of marrow smear was 58.31%. When it was 3 ＋ , the positive ratio of hyperplasia in marrow section was 41.67% and the positive ratio of marrow smear was 16.67%. The differences were significant （P〈0. 05）. Combination of bone marrow biopsy with bone marrow smear benefit the diagnosis and typing of MM. Conclusions Compared with general smear observation, Synchronism observation can increase the detectable rate.