复方鲨鱼软骨素对荷瘤小鼠免疫功能的影响

The effect of complex shark cartilage on immune function in tumor-bearing mice

目的:探讨复方鲨鱼软骨素对荷瘤小鼠免疫功能的影响。方法:采用动物移植性肿瘤S180实体瘤为实验模型,选用BALB/C小鼠进行碳廓清和DNCB迟发型超敏反应实验,并观察其对免疫器官的影响。结果:复方鲨鱼软骨素高、中、低3个剂量组能使小鼠网状内皮系统吞噬功能增强;高、中剂量组能增强小鼠DNCB所致迟发型超敏反应;中、低刺量组能使胸腺和脾指数增加。结论:复方鲨鱼软骨素能改善荷瘤小鼠的免疫功能。

Objective： To study the the effect of complex shark cartilage on immune function in tumor-bearing mice, Methods： The carbon clearance, DBFB delayed hypersensitivity, and immune organs were examined in tumor-bearing BALB/C mice. Results： Complex shark cartilage enhanced significantly the carbon clearance and DBFB delayed hypersensitivity and markedly increased the index of spleen and thymus in a dose-dependent manner. Conclusion： complex shark cartilage may enhance the suppressed immune function in tumor-bearing mice.