长期锻炼对老年男性瘦素、性激素及其结合蛋白水平的影响及意义

The significance and effect of long-term moderate-intensity exercise on sexual hormones, leptin and sexual hormone binding globin in aging males

目的通过研究探讨长期中等强度锻炼对老年男性性激素、瘦素和性激素结合球蛋白的影响。方法筛选从事游泳锻炼至少5年和长期不从事锻炼的非体力劳动、年龄在60岁以上的男性各40名,抽取空腹血,用放免方法检测性激素、性激素结合球蛋白和瘦素。结果长期锻炼组较对照组睾酮水平要高,而雌激素、性激素结合蛋白、瘦素水平低。结论长期中等强度的锻炼通过影响人体内性激素、性激素结合球蛋白、瘦素等水平给老年男性带来益处。

Objective To investigate the effects of long-term moderate-intensity exercise on sexual hormones, leptin and sexual hormone binding globulin in aging males. Methods 40 males over 60 years old who practiced sports （swimming） over five years and 40 healthy subjects over 60 years old with sedentary life style were recruited in the study. Subjects were weighed on a digital balance accurate to 0.1 kg. Height was obtained to the nearest 0.1cm using a wall-mounted stadiometer. Fasted blood samples were obtained from the objects before 9AM.Serum blood was centrifuged after lh at room temperature. Blood plasma samples were stored at -80℃ until further analysis .Plasma sexual hormones and leptin were studied with Radioimmuno-assay. Results Leptin levels were inversely associated with testosterone and positively associated with estradiol. Leptin levels were higher in the control group than in the exercise group, SHBG level were higher in control group than in the exercise group. Conclusion Long-term moderate-intensity exercise may be beneficial to aging male by influencing the concentrations of sexual hormones, leptin and sexual hormone binding globulin in the plasma.