新生儿缺氧缺血性脑病脑脊液及血清神经元特异性烯醇化酶检测及动态变化

Newborn infants hypoxic-isalchemic encephalo-pathy and neuron-specific enolase measurement and dynamic change

目的:探讨新生儿缺氧缺血性脑病(HIE)脑脊液和血清神经元特异性烯醇化酶(NSE)的动态变化。方法:测定56例HIE患儿急性期和恢复期脑脊液和血清NSE的水平,并与对照组比较。结果:HIE组急性期和恢复期脑脊液和血清NSE的水平均明显高于对照组(P<0.01);重度HIE较中度HIE明显升高,中度比轻度HIE明显升高,P均<0.01;轻度、中度、重度HIE及对照组脑脊液NSE均明显低于血清NSE,有显著性差异,P均<0.01。结论:HIE可引起脑脊液和血清NSE水平升高,脑脊液和血清NSE水平的升高呈正相关,HIE恢复期NSE仍维持在较高的水平,NSE水平与HIE的严重程度有关。

Objective： Discuss measurement and dynamic change of newborn infants hypoxic-isalehemic encephalo-pathy （HIE） and neuron-specific enolase. Method： Measure 56 cases of HIE infant＇s cerebrospinal fluid （CSF） and serum NSE during their paroxysm and relived period and compare with the sample group. Result： HIE group＇s CSF and serum in paroxysm and relived period NSE are obviously higher than those of sample group （P 〈 0.01 ）. Heavier HIE is remarkably higher than medium HIE while medium HIE is distinctively higher than light HIE （P 〈 0.01 ）. All sample groups HIE and NSE is remarkably lower than blood serum NSE （P 〈 0.01 ）. Conclusion： HIE will lead to the rise of CSF and serum NSE and NSE of CSF and serum is closely related. NSE in convalescence remains high. NSE level is related with period of disease.