纳洛酮和醒脑静治疗新生儿缺氧缺血性脑病的意识恢复及行为神经评分

Consciousness recovery and score of nerval behavior in neonate hypoxic ischemic encephalopathy treated by naloxone and Xingnaojing injection

目的:观察纳洛酮、醒脑静及二者联合治疗新生儿缺氧缺血性脑病(HIE)的效果与意识恢复及行为神经评分的关系。方法:对96例确认为中-重度HIE的患儿随机分为三组,单用纳络酮组32例,单用醒脑静组33例,两者联用组31例,疗程10￣14d。结果:单用组意识障碍恢复时间无明显差异(P>0.05),联合治疗组意识障碍恢复时间比单用组明显缩短,有显著性差异(P<0.01);联合治疗组新生儿行为神经评分(NBNA)也优于单用醒脑静组,有显著性差异(P<0.05)。结论:HIE患儿用纳洛酮与醒脑静联合治疗较单一治疗更有优势,缩短了疗程、改善了预后,对减轻HIE所致的脑损害有良好的应用价值。

Objective： To study the therapeutic efficacy of naloxone, xingnaojing injection and alliance for neonate hypoxic ischemic encepiralopathy （HIE）, and the relationship between conseiousness recovery and score in nerval behavior Methods： 96 patients who were diagnosed midrange or severity HIE were separated into 3 groups randomly. 32 patients were treated by naloxone, 33 patients were treated by xingnaojing injection, the rest were treated by both. The course of treatment continued 10 - 14 days. Results： The time of conscious disturbance recovery was not significant difference in single drug groups （P 〉 0.05）. The time of conscious disturbance recover）- in therapeutic alliance group was significant to shorten and have significant difference （P 〈 0.01 ）; the NBNA of the therapeutic alliance group significant outstrip the xingnaojing injection group and have significant difference （P 〈 0.05）. Conclusion： Combination of naloxone and xingnaojing injection treated HIE have more ascendancy than using any drug alone. The course of treatment was shortened and the prognosis was improved. The therapeutic alliance of naloxone and xingnaojing injection has well effect to lessen the brain injured by HIE.