大剂量免疫球蛋白治疗急性病毒性脑炎临床研究

The Clinical Research of Massive Dose Intravenous Immunoglobulins on Acute Viral Encephalitis

目的探讨静脉大剂量免疫球蛋白对急性病毒脑炎的辅助治疗作用.方法55例急性病毒性脑炎患者随机分为研究组(27例)和对照组(28例),研究组给予人免疫球蛋白(每d 0.25～0.3g/kg),连续冲击治疗5d.观察两组病人疗效、并发症、脑电图改变.结果两组病人显效率分别为51.9%和21.4%(p<0.05),有效率分别为85.2% 和53.6%(p<0.05)、并发症感染分别为7.4%、32.1%(p<0.05);治疗2周后中度及重度异常脑电图比率分别为18. 5%、46.4%(p<0.05).结论大剂量免疫球蛋白辅助治疗急性病毒性脑炎能提高疗效、减少并发症,值得临床推广.

Objective To evaluate the efficacy of Massive Dose Intravenous Immunoglobulins as adjunct in treatment of acute viral encephalitis. Methods Fifty - five patients with viral encephalitis were divided into a study group （n = 27 receiving IVlG 0.3g/kg for 5 days） and a control group （n = 28） to observe the therapeutic effect, the alteration of brain electric activity mapping（BEAM） and complications. Results Treatment with IVIG has increased the remarkable improvement rate （51.9% vs. 21.4 %, p 〈 0.05 ） and improvement rate（85.2% vs. 53.6% ,p 〈 0.05）, decreased the rate of BEAM with medium or severe abnormality（18.5% vs. 46.4% ,p 〈0.05） and compllcations（7.4% vs.32.1% ,p 〈0.05）. Conclusions Massive Dose Intravenous Immunoglobulins as adjunct in treatment of acute viral encephalitis is safe, and it can increase therapeutic effect, decrease complications , which is worth popularizing in clinical practice.