支气管动脉介入灌注化疗治疗中晚期肺癌

Pouring chemotherapy in the bronchus artery in treating middle and late lung cancer

目的观察支气管动脉灌注化疗治疗中晚期肺癌的临床疗效。方法采用Seldinger技术穿刺股动脉并尽可能超选后注入化疗药物,如确定导管头已超过胁间后动脉则缓慢注入0.5～1.0ml碘化油和国产顺铂乳剂以栓塞肿瘤血管。结果经2年观察治疗组有效率(CR+PR)达69.12%,而对照组为36.11%,两组差异显著(P<0.01);生活质量按卡氏评分治疗组与对照组相比显著提高(P<0.01);而毒副反应明显降低(P<0.01)。结论支气管动脉灌注化疗可作为中晚期肺癌常规治疗方法之一和手术前化疗方法,如超选肿瘤供血动脉后予以顺铂和碘化油乳剂栓塞肿瘤血管则可明显提高治疗效果和生存质量。

Objective： The clinical curative effect of pouring chemotherapy in the bronchus artery in treating middle and late lung cancer patients. Methods： Puncture thigh artery in the technology of Seldingerr and try to inject chemotherapy pharmaceuticals after surpassing selects. Once having made sure the pipe head has surpassed the posterior intercostal artery, then inject slowly 0. 5 ml-1.0 ml lipidol and malplatinum emulsion made domestically on purpose of blocking the tumor blood vessel. Results：After two year＇s observation, the effeciency of the curing group（CR ＋PR）has reached 69.12%, while the effeciency of the contrast group is just 36. 11%.The diference of these two groups is notable. （P 〈 0.01）; In Ka＇s Marking System, the life quality of the curing group increases remarkably compared with the contrast group （P 〈 0.01）; There is a clear reduction of poisonous byreaction. （P 〈 0. 01）. Conclusion：The pouring chemotherapy in the bronchus artery should be a conventional curing method of lung cancer and chemotherapy before surgical operation. So firstly select surpassingly the tumor blood vessel,then use malplatinum emulsion made domestically and lipidos to block the tumor blood vessel. This method can clearly raise the curing effect and the living quality.