开搏通与国产卡托普利降压效果的临床观察

Clinical observation of depressing high blood effect between captopril and national captopril

目的探讨开搏通与国产卡托普利的降压效果、顺应性、坚持治疗率及价—效关系。方法对需要药物治疗的高血压病人92例,随机、单盲分为开搏通(A)组、卡托普利(B)组,分别从小剂量单药开始,效果不佳者浅增量,仍不佳者加服双氢克尿噻至目标血压,分别计算单药降压有效的平均用量,观察两组降压效果、顺应性、坚持治疗率,并做价—效分析。结果两组降压效果,单药降压有效率、药物顺应性均无明显差异,卡托普利用量较大,为开搏通的2.8倍,按平均剂量计算费用,A组5.29元/d,B组0.36元/d。B组的坚持治疗率高于A组(82.6%对73.9%)。结论开搏通与卡托普利降压效果、顺应性无差别,两者只有量的差别为1:2.8,卡托普利价格便宜,易被病人接受,有较高的坚持治疗率。所以采用国产卡托普利的总体效益大于开搏通,并可节省药费、降低病人负担。

Objective： To contract captopril with national captopril in depressing high blood pressure effect, compliance, persistent treatment rate and the value- effect relationship. Methods： 92 hypertension patients who need to treat with medicine were divided by random into 2 groups： captopril group （A） and natonal captopril group（B）. They began to take small amount of effective dosage respectively, increasing the dose when effect disatisfactory or even adding to take DHCT to obtain the ideal BP.Value respectively the average effective dosage, observe the effect of depressing BP between the 2 groups as well as the compliance, persistent treatment rate. Analyse the value- effect relationship. Results： The depressing BP effect , single medicine effective rate and medicine compliance of these 2 groups hadn＇t obvious diversity; national captoprils dose was 2. 8 larger than that of captopril. If we value the cost according to the average dose, group A needs 5.29/d, while group B 0. 36/d. The persistent treatment rate of group B is higher than group A（82.6% vs 73.9% ）. Conclusons： There are no different between captopril and national captopril in depressing BP and compliance. The dose balance is 1： 2. 8. national captopril is cheaper and easy to be accepted which results in high persistent treatment rate. This demonstrates national captopril＇s total benefit is more than captopril and it＇ll save the medicine cost.