银杏内酯对犬脑血流量的影响

Effects of ginkgolide on cerebral blood flow in dogs

目的 :观察银杏内酯对犬脑血流量的影响。方法 :将麻醉犬随机分为 5组 ,每组 4只 ,溶剂对照组灌胃食用油 (1ml/kg) ,阳性药物对照组灌胃杏灵颗粒 (0 .2 2g/kg) ,受试药物各剂量组灌胃银杏内酯 (分别为4 .86、14 .6、4 3.7mg/kg) ,给药后不同时间点分别记录颈内动脉血流量、血压、心电图、心率 ,并进行对照分析。结果 :银杏内酯 4 .86、14 .6、4 3.7mg/kg灌胃 ,对麻醉犬血压、心率无显著影响 ;14 .6及 4 3.7mg/kg灌胃 90min后使脑血流量显著增加 ,4 3.7mg/kg灌胃 15 0min后可显著减少脑血管阻力。 结论 :银杏内酯可降低麻醉犬脑血管阻力 ,增加脑血流量 ,不影响心率及血压。

Objective： To observe the effects of ginkgolide （GL） on the cerebral blood flow in dogs.Methods： Dogs anesthetized with sodium pentobarbital were randomly divided into 5 groups, with 4 dogs in each group. Ginkgolide of 4.86, 14.6 and 43.7 mg/kg and Xingling Granule of 0.22 g/kg were administered by gavage to the dogs in each of 4 groups. The dogs in the other group were administered with edible oil（1 ml/kg） as control group. The cerebral blood flow, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and electro-cardiogram of the dogs were measured at different times after the administration. Results. Ginkgolide of 4.86, 14.6 and 43.7 mg/kg had no obvious effects on the blood pressure and the heart rate. Ginkgolide of 14.6 and 43.7 mg/kg increased the cerebral blood flow 90 minutes after administration, and ginkgolide of 43. 7 mg/kg obviously decreased the cerebral vascular resistance 150 minutes after administration. Conclusion： Ginkgolide can increase the cerebral blood flow and decrease the cerebral vascular resistance, and it has no obvious effects on blood pressure and heart rate in dogs.