期刊文献+

安神中药药理研究方法综述 被引量:13

Survey on pharmacological methodology of sedative Chinese materia medica
下载PDF
导出
摘要 安神中药药理研究的主要实验方法有自主活动测试(抖笼法、空场实验、洞板实验等)、睡眠实验、对抗中枢兴奋实验。关于自主活动主要的评价指标有动物的活动次数、走格数、运动路程、钻头次数及持续时间;睡眠实验的指标有睡眠动物数、睡眠潜伏期和持续时间;对抗中枢兴奋实验的指标有惊厥动物数、惊厥潜伏期和持续时间。针对现有的实验方法、评价指标及其意义进行综述,为建立适合中医药特点的安神中药药理研究方法提供参考。
出处 《中草药》 CAS CSCD 北大核心 2005年第8期1257-1260,共4页 Chinese Traditional and Herbal Drugs
基金 国家中医药管理局中医药留学回国人员科技活动择优资助课题(2003LHR01)
关键词 安神 药理方法 中药 自主活动测试 睡眠实验 对抗中枢兴奋实验 nourishing heart and tranquilizing pharmacological methods Chinese materia medica
  • 相关文献

参考文献25

  • 1赖飞,曾靖,黄贤华,叶和扬,朱遵平,杨敬格.淫羊藿水提取液中枢抑制作用的研究[J].赣南医学院学报,2003,23(3):268-270. 被引量:11
  • 2WangXP ChenQM ZhengXX.Study on the sedative hypnotic effect of Sophora flavescens Air. ethanol on the central nervous system in mice [J].中草药,2004,35(5):551-553.
  • 3封洲燕,郭殿武,苏松,赵辉,郑筱祥.酸枣仁皂甙A镇静和抗惊厥作用试验[J].浙江大学学报(医学版),2002,31(2):103-106. 被引量:26
  • 4Lang U E, Lang F, Richter K, et al. Emotional instability but intact spatial cognition in adenosine receptor 1 knock out mice [J]. Behav Brain Res, 2003, 145(1-2): 179-188.
  • 5XuXP HuR XiZF.Pharmacodynamic studies on Compound Suanzaoren Decoction[J].西北药学杂志,2002,17(5):210-212.
  • 6ZhaoZQ LuYM YuJH etal.Pharmacodynamicstudies on the effect of Tianma Gouteng Decoction etc. three prescriptions on spontaneous motor activity in mice [J].中药药理与临床,1999,15(1):6-7.
  • 7Madani R, Kozlov S, Adhmedov A, et al. Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin [J]. Mol Cell Nenrosci, 2003, 23(3) :473-494.
  • 8Choleris E, Thomas A W, Kavaliers M, et al. A detailed ethologieal analysis of the mouse open field test: effeets of diazepam, eholrdiazepoxide and an extremely low frequency pulsed magnetie field [J]. Neurosci Biobehav Rev, 2001, 25(3): 235-260.
  • 9王一奇,朱朝阳,魏尔清.不同品系小鼠自发活动特点及中枢抑制药新评价模型[J].科技通报,2003,19(4):292-296. 被引量:18
  • 10Schmitt U, ltiddens H, Hiemke C. Behavioral effects of GABA (A) receptor stimulation and GABA-transporter inhibition [J]. Pharmacol Biochem Behaz,, 2000, 65 (2): 351-356.

二级参考文献38

  • 1许兰芝,陈维宁.淫羊藿总黄酮对肾上腺素能受体阻断作用的研究[J].中国药理学通报,1994,10(4):311-313. 被引量:64
  • 2刘崇铭,王敏,梁利春.淫羊藿黄酮对脑血流与脑缺血的作用[J].沈阳药科大学学报,1995,12(3):192-194. 被引量:52
  • 3库宝善 徐叔云 卞如濂.催眠药物实验法[A].徐叔云,卞如濂.药理实验方法学 第3版[C].北京:人民卫生出版社,2002.804~807.
  • 4李时珍(明).本草纲目(十二卷,校点本).第一版.第二册[M].北京:人民卫生出版社,1977.751.
  • 5Carey R, Damianopoulos E, Palma G.8-OH DPAT can restore the locomotor stimulant effect of cocaine blocked by haloperidol [ J ].Pharmacol Biochem Behav, 2000, 66(4): 863-872.
  • 6Antoniou K, Kafetzopoulos E, Papadopoulou-Daifoti Z, et al. Damphetamine, cocaine and caffeine: a comparative study of acute effects on locomotor activity and behavioural patterns in rats [J]. Neurosci Biobehav Rev,1998, 23(2):189-196.
  • 7Thiel C, Muller C, Huston S, et al . High versus low reativity to a novel environment: behavioural, pharmacological and neurochemical assessments [J]. Neuroscience, 1999, 93(1):243-251.
  • 8Paulus M, Dulawa S, Ralph R, et al . Behavioral organization is independent of locomotor activity in 129 and C57 mouse strains [J].Brain Res, 1999, 835(1): 27-36.
  • 9Merce C, Marta M, Carles S, et al . Effects of chronic lead adminiatraion on ethanol-induced locomotor and brain catalase activity [J].Alcohol, 1999, 19(1):43-49.
  • 10Adam M, Emma S, Joseph R. Fluoxetine-induced increases in openfield habituation in the olfactory bulbectomized rat depend on test on aversiveness hut not anxiety [ J ]. Pharmacol Biochem Behav, 2002,73(3) :703 - 712.

共引文献209

同被引文献216

引证文献13

二级引证文献187

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部