摘要
目的:探讨体重指数(BMI)对接受广泛性子宫切除术的子宫颈癌Ⅰb期患者预后的影响。方法:回顾性分析1987年4月～1997年4月行广泛性子宫切除的子宫颈癌Ⅰb期患者87例,根据BMI不同将其分为3组,即BMI-S组(BMI<20)23例;BMI-M组(20≤BMI<27)48例;BMI-L组(BMI≥27)16例。分析3组5年生存率及预后因素的关系。结果:BMI-S组、BMI-M组及BMI-L组5年生存率分别为64.3%、87.9%及91.3%;BMI-S组与BMI-M组、BMI-L组之间比较,有显著性差异(P<0.05)。各组间年龄、组织学类别、细胞分化程度、淋巴结转移率、平均肿瘤直径比较,无显著性差异(P>0.05)。BMI-S组与BMI-M组、BMI-L组有深肌层浸润者分别为82.6%、50.2%、37.9%,BMI-S组与BMI-M组、BMI-L组之间比较,有显著性差异(P<0.05)。采用COX模型多变量分析结果表明,平均肿瘤直径(P<0.01)、有无淋巴结转移(P<0.05)及BMI<20(P<0.01)是影响预后的独立因素。结论:体重指数与子宫颈癌Ⅰb期预后有关,低体重患者预后较差。
Objective： To evaluate the effect of body mass on survival and morbidity of the patients with FIGO Stage Ib cervical cancer treated with radical hysterectomy. Methods： Medical records from all patients with FIGO （1995） stage IB cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy （RH ＋ PLND）, from 1987 to 1997, were retrospectively reviewed. According to body mass index （BMI）, the 87 cases with stage Ib cervical cancer were divided into three groups： BMI-S in 23 cases （BMI〈20）, BMI-M in 48 cases（20≤〈BMI〈27）and BMI-L in 16 cases （BMI≥27）. Data collected included patients, age, pathological type, tumor size, degree of differentiation, depth of cervical invasion （DCI）, lymph node metastasis, operating time, estimated blood loss, transfusion, and follow-up data. Results： There was no significant differences in age, DCI, or pelvic node metastasis, cell type, cell differentiation and tumor size. The five-year disease-free survival was 64.3% for BMI-S, 87.9% for BMI-M and 91.3% for BMI-L, respectively. Significant differences were observed between BMI-S and BMI-M, as well as BMI-S and BMI-L. DCI of group BMI-S was also significantly different from other two groups （P〈0.05）. Pelvic node metastasis （P〈0.05）, tumor size （P〈0.01） and BMI-S （P〈0.01） were independent poor prognostic indicators. Conclusion： Low BMI is a poor predictor for survival of the patients with FIGO stage Ib.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2005年第14期808-810,共3页
Chinese Journal of Clinical Oncology
