不孕症自身抗体HCGA与生殖激素水平关系的研究

Study on the correlation between anti-human chorionic gonadotropin antibodies and the levels of reproductive hormone in infertility

目的 研究不孕症妇女血清抗 HCG抗体(anti humanchorionicgonadotropineantibody ,HCGA)与生殖激素水平的关系。方法 用放射免疫法检测不孕症妇女血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2 )、孕酮(P)水平,用ELISA间接法定性检测HCGA。结果 HCGA阳性组(2 5例)FSH水平显著高于HCGA阴性组(73例) ,而LH、E2 、P水平显著低于HCGA阴性组。结论 HCGA可能是引起生殖激素水平改变而导致不孕的重要因素之一。

Objective To explore the correlation between anti-human chorionic gonadotropin antibody（HCGA）and the levels of reproductive hormone in women with infertility. Methods Levels of FSH, LH, E2 and P were determined by RIA and qualitative examination of serum HCGA was measured with ELISA. Results In women with infertility, the serum levels of FSH with positive HCGA（ n = 25） were obviously higher than those with negative HCGA（ n = 73）while the levels of E2, P and LH were obviously lower. Conclusion HCGA may be one of the main factors for women with infertility in changing the levels of reproductive hormone.