胃癌患者高血小板血症与预后关系的研究

A study on the correlation between thrombocytosis and clinicopathological in patients with gastric cancer

目的研究胃癌患者高血小板血症与胃癌临床病理因素和预后的关系。方法回顾性分析1986—1996年间我院外科手术治疗的366例胃癌患者外周血的血小板计数(PLT)和血红蛋白(Hb)浓度,分析高血小板血症和贫血的发生率,比较高血小板血症和正常血小板计数胃癌患者的临床病理因素及预后的差别。结果胃癌患者高血小板血症发生率为24·6%,贫血发生率为54·1%,PLT与Hb呈负相关关系。高血小板血症与胃癌的肿瘤大小、淋巴结转移和浆膜浸润相关。高血小板血症胃癌患者的1、3、5年生存率分别为50·4%、32·7%和20·2%,明显低于血小板正常者的82·8%、69·3%和40·1%。除淋巴结转移和浆膜浸润外,高血小板血症是胃癌患者的独立预后因素。结论高血小板血症是影响胃癌患者生存的独立预后因素。

Objective To study the prevalence of thrombocytosis in patients with gastric cancer and its correlation with clinicopathological features. Methods Platelet count （PLT） and hemoglobin concentrations （Hb） were analyzed retrospective in 366 patients with gastric cancer from 1986 to 1996. Thrombocytosis was defined as PLT at or 〉 400 × 10^9/L and anemia was defined as Hb 〈 120 g/L in men and 〈 110 g/L in women. The survivals of gastric cancer was compared between normal PLT group and thrombocytosis group. Results Thrombocytosis was found in 24. 6% patients, and anemia in 54. 1% patients. PLT was negatively correlated with Hb. There was a positive correlation between tumor size, lymph node metastasis and serosal invasion and PLT. One-, 3- and 5-year survivals in patients with or without thrombocytosis were 50. 4% , 32.7% , 20.2% and 82. 8% , 69. 3% , 40. 1% , respectively. PLT was identified as an independent prognostic factor after lymph node metastasis and serosal invasion. Conclusion Thrombocytosis is an independent prognostic indicator of survival in patients with gastric cancer undergoing gastrectomy.