摘要
ADAM33基因定位于20号染色体短臂20p13,属于ADAM基因超家族。ADAM基因超家族编码的蛋白质具有金属蛋白酶活性,这种活性与多种疾病的发生相关。在不同人群中的病例对照及家系研究提示ADAM33基因可作为哮喘的候选基因,其抑制剂有望用于哮喘病的治疗。
A disintegrin and metalloprotease-encoding gene （ADAM） 33, located on the short arm of chromosome 20 （20p13）, was recently identified through a genome-wide scan for asthma. It is a new member of a family of genes encoding a group of the metalloproteinase superfamily called the ADAM family. The proteolytic activity of the ADAMs plays an important role in the healthy and disease states. The identification of ADAM33 as a candidate gene for asthma may provide a newly therapeutic target for this disease.
出处
《遗传》
CAS
CSCD
北大核心
2005年第4期636-640,共5页
Hereditas（Beijing)
基金
国家自然科学基金(编号:30200161
30370627
30370628)~~
