肝硬化高氨血症与幽门螺杆菌的关系

Helicobacter polyri and hyperammonaemia in patients with liver cirrhosis

目的 研究探讨幽门螺杆菌（Hp）感染与肝硬化高氨血症的关系。方法 对60例肝硬化病人进行抗Hp治疗，观察治疗前后血氨浓度的变化。结果 2001-03／2003-06收住的肝硬化病人60例，Hp感染阳性42例（A组），占61.0％，阴性者18例（B组），占39．0％。Hp阳性者血氨为151．0±36．5μmol／L，阴性者血氨为121．3±37．6μmol／L，两者有显著差异（P〈0．01）。Hp阴性者在治疗后血氨水平无显著性下降（P〉0．05）。结论 在Hp阳性的肝硬化病人中，血氨水平的升高与Hp感染有关，根治Hp后可以降低血氨的浓度，对防止肝性脑病的发生可能有一定的临床意义。

AIM To study the relationship between infection of Helicobacter polyri （Hp） and hyperammonaemia in patients with liver cirrhosis. METHODS Sixty patients with cirrhosis were treated with losec, amcillin and metronidazole for one week for theeradication of Hp. RESULTS Pre- treatmen blood ammonia was higher （151.0±36.5 vs 121.3±37.6μmol/L, P 〈0.05）in Hp positive group（n= 42） than in Hp negative group （n= 18）. Blood ammonia was decreased significantly after treatment in Hp positive group（111.5 ± 23.9μmol/L, P 〈0.01）,but not significantly in Hp negative group（117.3±28.6μmol/L, P 〉0.05）. CONCLUSIONS Hp infection plays some role in the elevation of blood ammonia in liver cirrhosis. Hp eradication can help decrease blood ammonia and prevent hepatic encephalopathy.