摘要
目的 评价胃癌腹腔化疗的毒副反应，并探讨其处理方法。方法 将156例胃癌病人进行随机分组。分为术中即时低渗温热腹腔化疗联合术后早期腹腔化疗组（治疗组），单纯术中即时低渗温热腹腔化疗组（对照组1），未行腹腔化疗组（对照组2），共三组，观察化疗的安全性和毒副反应。结果 治疗组化学性腹膜炎、消化道反应、骨髓抑制和肝功能异常的发生率明显高于两个对照组。结论 应用术中即时，低渗温热腹腔化疗联合术后早期腹腔化疗时化学性腹膜炎的防治不容忽视。
AIM To evaluate the toxic and side effect of intraperitoneal chemotherapy （IPC） for gastric cancer. METHODS Patients with gastric cancer were randomized into 3 groups receiving intraoperative hypotonic chemo-hyperthermia（n = 49）, or in addition,early postoperative IPC （n= 52）, or no IPO（n = 55）. All patients had routine postoperative transvenous chemotherapy. RESULTS The incidence rates of chemical peritonitis, gastrointestinal disturbance, bone marrow depression and hepatotoxicity in the second group were significantly higher than those in the other two groups（ P 〈0.05）. CONCLUSION Much attention should be paid to the toxic and side effect in patients receiving intra - as well as post-operative IPC.
出处
《中华腹部疾病杂志》
2005年第9期634-635,共2页
Chinese Journal of Celiopathy
关键词
胃癌
腹腔脱落细胞
腹腔化疗
毒副反应
化疗
Gastric cancer
Intraperitoneal chemotherapy
Toxic and side effect
