卡维地洛治疗轻中度高血压疗效观察

The efficay of carvediolo on patients with mild to moderate essential hypertension

目的评价第三代新型β受体阻滞剂卡维地洛治疗轻、中度高血压患者的疗效和安全性。方法采用随机、单盲、氨氯地平对照方法,86例患者按1∶1随机分入卡维地洛组或氨氯地平组,每天一次口服卡维地洛10mg或氨氯地平5mg,每周复查血压1次,如未达降压标准(≥140/90mmHg,1mmHg=0.133kPa)者,则每周递增卡维地洛10mg,最大为50mg/d;或氨氯地平增加至10mg,共治疗8周。结果8周末,两组患者坐位平均收缩压和舒张压均较前有显著下降(P<0.01),两组的降压总有效率分别为79.0%和76.7%,(P>0.05),卡维地洛与氨氯地平SBP的T/P值分别为(62.1±4.5)%、(64.6±4.9)%(t=0.44,P>0.05);DBP的T/P值分别为(71.4±5.3)%、(69.6±6.8)%(t=0.73,P>0.05)。心率变化,卡维地洛组用药后虽有下降趋势,但无显著统计学改变,氨氯地平组心率无明显变化。副作用发生率分别为11.6%和18.6%,主要表现为头昏、头痛、睡眠差、水肿,程度较轻。结论卡维地洛控制血压的疗效和耐受性与氨氯地平相似,每天一次服药能平稳控制高血压患者24h血压。

Objective To explore and evaluate the efficacy and the safety of the patients with mild to moderate essential hypertension ,applying Carvedilol. Methods Retrospectively analyzing the clinical data of 86 cases of patients with mild to moderate essential hypertension ,which is randomly （1：1） divided into an experimental group, applying carvedilol.and a compared one, applying amlodipine , to explore and analyze the the efficacy and the safety of the patients of these two groups. With the normal eight-week treatment , weekly applying （orally）5 mg/d of Amlodipine, if the patients’ BP＇s under 140/90 mm Hg, increase weekly the dosage ,up to the biggest bearable dosage,10 mg/d of Amlodipine in the compared group, and the experimental one, 10 mg/d of Carvedilol ; if the patients＇ BP＇s under 140/90 mm Hg, increase weekly ,up to the biggest bearable dosage, 50 mg/d of Carvedilol .During eight weeks’ experimental treatment, to recheck the data of the patients＇ BP＇s per week. Results The BP＇s in both the experimental and the compared group decrease effectively （P〈0.01）： 79.0% ,efficiently in the experimental group, and the compared one, 76.7% ,efficiently ,P〉0.05. The T/P＇s of SBP on Carvedilol and Amlodipine are （52.1±4.5）% ,（64.6±4.9）% （t= 0,44,P〉0.05）;The T/P＇s of DBP on Carvedilol and Amlodipine are （71.4±5.3）% ,（69.6±6.8）% （t= 0.73,P〉0.05）. And the occurrences of side effects are 11.6 %（with Carvedilol） and 18.6%（with Amlodipine ） . The main symptoms are dizzinesses,headache. Conclusions The eight weeks＇ treatments for the patients of these two groups , hints the treatment,applying Carvedilol have an obvious control of BP＇s ,and this research shows that the patients have the average bearability in applying Carvedilol and Amlodipine are similar. The daily dosage mentioned above can steadily control the patients＇ BP＇s in the period of 24 hours.