糖尿病患者的肺功能变化及其临床意义

A STUDY OF PULMONARY FUNCTION IN PATIENTS WITH DIABETES MILLITUS

用ＣＨＥＳＴ－２５型肺功能仪测定４９例糖尿病患者和３７名正常人的肺容量、流速一容量曲线及肺弥散功能。结果示糖尿病患者的ＶＣ、ＶＣ％、ＦＥＶＩ％、ＭＶＶ、ＭＶＶ％、ＲＶ、ＦＲＣ和ＴＬＣ等与正常人接近，而ＤＬｃｏ、ＤＬｃｏ％、ＤＬｃｏ／ＶＡ和ＤＬｃｏ／ＶＡ％明显降低。病程在６年以上和伴有其它并发症者下降更显著。Ｉ型糖尿病患者和空腹血糖及糖化血红蛋白浓度高者弥散功能也较差。糖尿病患者弥散功能障碍可能与糖尿病性肺部微血管病变和蛋白的非酶糖基化有关。

The pulmonary function was assessed in 49 cases of diabetes mellitus and 37 normal controls. The result showed that the values of VC, VC%, FEV1%, MVV, MVV%. RV, FRC and TLC in patients with diabetes mellitus had no significant difference from those in controls. But the values of DLco, and DLco/VA were significantly reduced in diabetic patients （P〈0. 01 ）, especislly in those with a duration of illness longer than 6 years and those with severe complications. The development of disorder of diffusing capacity in patients with diabetes mellitus may be related to the lung microvaseulopathy and nonenzymatic glycosylation in lung tissues.