乙酰苯胺选择性硝化最佳工艺条件研究

The Study on the Best Technological Conditions of Selective Nitration of Acetanilide

乙酰苯胺经选择性硝化可得重要的有机中间体对硝基乙酰苯胺。目前工业上采用混酸低温硝化．反应时间长，能耗大．该文通过乙酰苯胺硝化的单因素及正交试验、得到了制备对硝基乙酰苯胺的最佳工艺条件，与现行工艺相比，反虑温度由5℃提高到20℃，反应时间由20h缩短到2h，降低生产成本，提高生产能力。

Selective nitration of acetanilide provides 4-nitroacetanilide, served as useful intennediates. At present it is carried out in mxied acid at low temperature, therefore the long reaction time and more energy consumption are required. In this paper the best technological conditions for preparing 4-nitroacetanilide are obtained through parameters and orthogonal test. Compared with the existing methods, the reaction temperature is raised from 5℃ to 20℃ and the reaction time reduced from 20 h to 5 h, therefore the productioncost is cut down and the productivity is raised.