注意缺损多动障碍和儿茶酚-O-甲基转移酶基因无关联性(英文)

No Association Between Attention-Deficit Hyperactivity Disorder and Catechol-O-Methyltransferase Gene in Chinese

以往研究表明,儿茶酚胺系统可能参于注意缺损多动障碍(attentiondeficithyperactivityitydisorder,ADHD)的发生,而儿茶酚胺O甲基转移酶(catechelomethyltransferase,COMT)是一种降解多巴胺和去甲肾上腺素系统的儿茶酚胺神经递质的酶。因此,采用两种以家系为基础的分析方法,即传递不平衡实验(transmissiondisequilibriumtest,TDT)和单倍型为基础的单倍型相对风险率(haplotypebasedhaplotyperelativerisk,HHRR)去探讨COMT和中国人群中79个ADHD核心家系的关联性,ADHD诊断符合DSMIV的诊断标准。TDT(χ2=1.03,df=1,P>0.05)和HHRR(χ2=1.08,df=1,P>0.05)两种方法的分析结果表明,COMT等位基因不能优先传递给ADHD儿童,提示在中国人群中ADHD与COMT基因无关联性。

Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder（ADHD）, Since catechel-o-methyltransferase（COMT） is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems,it is possible that COMT may play a role in ADHD, To test this hypothesis,we used two family-based analyses,the transmission disequilibrium test （TDT） and the haplotype-based haplotype relative risk （HHRR）, to examine the possible association between COMT gene and DSM-IV-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT （X^2 =1.03,df=1 ,P〉0. 05） and HHRR （X^2 =1.08,df= 1, P 〉 0.05） analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Our data suggested that there was no association between ADHD and the COMT gene in the Chinese population.